The MenT3 toxin of Mycobacterium tuberculosis, the bacterium that causes pulmonary tuberculosis in humans, inactivates tRNA by adding nucleotides to the 3′-CCA end of its own tRNA, thereby suppressing the bacterium’s growth. In this study, we elucidated the substrate specificity and molecular mechanism of the MenT3.　” Substrate specificity of Mycobacterium tuberculosis tRNA terminal nucleotidyltransferase toxin MenT3” Nucleic Acids Res. (2024) doi.org/10.1093/nar/gkae177

ヒトに肺結核を引き起こす結核菌（Mycobacterium tuberclosis)のMenT3蛋白質は自身のtRNAの3′-CCA末端にヌクレオチドを付加することによりtRNAを不活性化し、結核菌自身の増殖を抑制する機能があります。今回、MenT3トキシンの基質特異性とその分子機構を明らかにしました。” Substrate specificity of Mycobacterium tuberculosis tRNA terminal nucleotidyltransferase toxin MenT3” Nucleic Acids Res. (2024) doi.org/10.1093/nar/gkae177